Henry, Jessie, Violet and Benny are four orphaned brothers and sisters who mysteriously appear in a small town on a warm summer night. No one knows who these young wanderers are or where they have come from. Frightened to live with a grandfather they have never met, the children make a home for themselves in an old abandoned red boxcar they discover in the woods. Henry, the oldest, goes to town to earn money and buy food and supplies while the other kids make a home in the boxcar finding old dishes and scraps in a junkyard. Ambitious and resourceful, the plucky children make a happy life for themselves. As time passes, they discover the struggles and rewards of independence as well as the joys of family - until one day Violet gets too sick for her brothers and sister to care for her. They must take Violet to a doctor risking discovery and the loss of their secret home in the forest.

Trained in the skills of sea power, Pi the fish can fight a shark, sink a squid or batter any random predator that ever threatens his friends and neighbors on the reef. Unfortunately, being the only hero in town can take its toll, especially when a group of sharks declares that the end of the reef is soon at hand.

Samantha's band, the Zettabytes, is meeting with little success, so her friend Roscoe uses his knowledge of technology designed by his father to create a holographic lead singer, Loretta Modern. The band instantly becomes successful, but Samantha begins to feel alienated, Roscoe discovers feelings for Samantha, and Loretta struggles with individuality.

Nothing in the world can make Garfield get involved in anything besides eating, until the muscular super cat Garzooka comes crashing into Cartoon World from the Comic Book universe with terrifying news. Garfield summons up the willpower to join his superhero Garzooka in a fight to save their worlds.